Galaktozilgalaktozilksilozilprotein 3-beta-glukuronoziltransferaz 3, insanlarda B3GAT3 geni tarafından kodlanan bir enzimdir.
Protein, glukuroniltransferaz gen ailesinin üyesi olan bu gen tarafından kodlanmıştır; sıkı alıcı özgüllüğü sergileyen enzimler, indirgenmeyen terminal şekerleri ve bunların anomerik bağlantılarını tanır. Bu gen ürünü, proteoglikanların bağlantı bölgesinin biyosentezinin son aşamasında bir glukuronil transfer reaksiyonu yoluyla glikozaminoglikan-protein bağlantısının oluşumunu katalizler.
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
- ^ "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8.
- ^ a b "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
Dış bağlantılar
- Human B3GAT330 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and B3GAT3 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: O947667 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB.
Konuyla ilgili yayınlar
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8.
- "Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair". Proc. Natl. Acad. Sci. U.S.A. 101 (52). 2005. ss. 18087-92.
- "Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 280 (2). 2005. ss. 1417-25.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7.
- "The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif". J. Biol. Chem. 278 (34). 2003. ss. 32219-26.
- "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). 2003. ss. 16899-903.
- "Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization". Biochem. J. 358 (Pt 3). 2001. ss. 539-46.
- "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I". J. Biol. Chem. 275 (44). 2000. ss. 34580-5.
- "Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues". J. Biol. Chem. 275 (36). 2000. ss. 28254-60.
- "Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". FEBS Lett. 459 (3). 1999. ss. 415-20.
- "Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway". Proc. Natl. Acad. Sci. U.S.A. 96 (3). 1999. ss. 974-9.